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KMID : 0369820090390010013
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 1 p.13 ~ p.18
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Parenteral Docetaxel Emulsion System and Its Stability
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Kim Hyun-Jo
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Abstract
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Docetaxel is an anticancer agent with low aqueous solubility. More extensive clinical use of this drug is somewhat delayed due to lack of appropriate delivery vehicles. An attempt was made to adopt an o/w emulsion as the drug carrier which incorporated docetaxel in the propyleneglycerol stabilized by a mixed-emulsifier system. A suitable formulation was found in this study: 10 mg/mL docetaxel, 10% (w/v) oil blend, 4% (w/v) PG, 3% (w/v) Solutol HS 15 in 2.25% (w/v) glycerol solution. The formulated emulsion has very good stability when stored at , and the docetaxel containment efficiency can be maintained above 95% and the mean emulsion diameter around for at least 3 months. The formulated emulsion is a promising carrier for docetaxel and other lipophilic drugs.
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KEYWORD
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Emulsion, Docetaxel, Anticancer therapy, Drug delivery system, Stability
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